Title : Neurotoxicity of the organochlorine insecticide heptachlor to murine striatal dopaminergic pathways.

Pub. Date : 2001 May

PMID : 11294980






2 Functional Relationships(s)
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1 Significant increase in V(max) of striatal DAT was not observed at doses > 12 mg/kg, which suggested that toxic effects of heptachlor epoxide may be responsible for loss of maximal dopamine uptake observed at higher doses of heptachlor. Heptachlor solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus
2 At doses of 6 and 12 mg/kg heptachlor, which increased expression of striatal DAT, uptake of 5-hydroxytryptamine into cortical synaptosomes was unaffected. Heptachlor solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Mus musculus