Protein Name solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Organism Mus musculus
Gene ID 13162
Gene Symbol

Slc6a3

UniProt Q61327 (SC6A3_MOUSE)
Relationships Total Number of functionally related compound(s) : 279
Total Number of Articles : 545
Description

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Gene Summary

Enables several functions, including dopamine binding activity; dopamine:sodium symporter activity; and protein N-terminus binding activity. Involved in dopamine uptake; hyaloid vascular plexus regression; and neurotransmitter uptake. Acts upstream of or within several processes, including dopamine metabolic process; gland development; and prepulse inhibition. Located in axon and cell surface. Is expressed in genitourinary system; nervous system; spleen; and submandibular gland. Used to study Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and schizophrenia. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • sodium-dependent dopamine transporter
  • DA transporter
  • dopamine transporter 1
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Properties