Pub. Date : 2001 Mar
PMID : 11294598
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of trans-resveratrol on 7-benzyloxy-4-trifluoromethylcoumarin O-dealkylation catalyzed by human recombinant CYP3A4 and CYP3A5. | Resveratrol | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | Effect of trans-resveratrol on 7-benzyloxy-4-trifluoromethylcoumarin O-dealkylation catalyzed by human recombinant CYP3A4 and CYP3A5. | 7-benzyloxy-4-trifluoromethylcoumarin | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | Trans-resveratrol inhibited BFC O-dealkylation catalyzed by CYP3A4 and CYP3A5 in a concentration-dependent manner. | Resveratrol | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 4 | Trans-resveratrol inhibited BFC O-dealkylation catalyzed by CYP3A4 and CYP3A5 in a concentration-dependent manner. | 7-benzyloxy-4-trifluoromethylcoumarin | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 5 | The apparent Ki values (mean +/- SEM) for the inhibition by trans-resveratrol of BFC O-dealkylation catalyzed by CYP3A4 and CYP3A5 were 10.2+/-1.1 microM and 14.7+/-0.3 microM, respectively. | Resveratrol | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 6 | The apparent Ki values (mean +/- SEM) for the inhibition by trans-resveratrol of BFC O-dealkylation catalyzed by CYP3A4 and CYP3A5 were 10.2+/-1.1 microM and 14.7+/-0.3 microM, respectively. | 7-benzyloxy-4-trifluoromethylcoumarin | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 7 | Overall, our study provides the first demonstration that trans-resveratrol inhibits, in vitro, a substrate oxidation reaction catalyzed by human recombinant CYP3A4 and CYP3A5. | Resveratrol | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |