Pub. Date : 2001 Apr
PMID : 11283850
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Addition to the cell cultures of PGE(2) promoted the release of MMPs through a mechanism that involved the expression of COX-2 and the synthesis of additional PGs. | Dinoprostone | matrix metallopeptidase 2 | Rattus norvegicus |
| 2 | Addition to the cell cultures of PGE(2) promoted the release of MMPs through a mechanism that involved the expression of COX-2 and the synthesis of additional PGs. | Prostaglandins | matrix metallopeptidase 2 | Rattus norvegicus |
| 3 | Kinetic analysis of the secretion of MMPs in response to LPS and PGE(2) showed a similar time course, with a lag period of 6 hours, which suggests that PGE(2) does not act directly on the mechanism of MMP processing and release. | Prostaglandins E | matrix metallopeptidase 2 | Rattus norvegicus |
| 4 | Kinetic analysis of the secretion of MMPs in response to LPS and PGE(2) showed a similar time course, with a lag period of 6 hours, which suggests that PGE(2) does not act directly on the mechanism of MMP processing and release. | Prostaglandins E | matrix metallopeptidase 2 | Rattus norvegicus |
| 5 | Kinetic analysis of the secretion of MMPs in response to LPS and PGE(2) showed a similar time course, with a lag period of 6 hours, which suggests that PGE(2) does not act directly on the mechanism of MMP processing and release. | Prostaglandins E | matrix metallopeptidase 2 | Rattus norvegicus |
| 6 | Kinetic analysis of the secretion of MMPs in response to LPS and PGE(2) showed a similar time course, with a lag period of 6 hours, which suggests that PGE(2) does not act directly on the mechanism of MMP processing and release. | Prostaglandins E | matrix metallopeptidase 2 | Rattus norvegicus |
| 7 | Inhibitors of protein kinase A, p38 MAP kinase, phosphatidylinositol-3-kinase, and nuclear factor kappaB (NF-kappaB) activation impaired the release of MMPs in response to PGE(2) challenge, indicating the involvement of multiple steps in the process. | Prostaglandins E | matrix metallopeptidase 2 | Rattus norvegicus |