Title : ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999.

Pub. Date : 2001 Mar 16

PMID : 11104774






9 Functional Relationships(s)
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1 ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens
2 ADP was subsequently shown to inhibit forskolin-stimulated adenylyl cyclase activity through selective activation of SP1999 with an EC(50) of 60 nM. Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens
3 ADP was subsequently shown to inhibit forskolin-stimulated adenylyl cyclase activity through selective activation of SP1999 with an EC(50) of 60 nM. Colforsin purinergic receptor P2Y12 Homo sapiens
4 Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). 2-methylthio-ATP purinergic receptor P2Y12 Homo sapiens
5 Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). methylthio-ADP purinergic receptor P2Y12 Homo sapiens
6 Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). Adenosine Diphosphate purinergic receptor P2Y12 Homo sapiens
7 Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). adenosine 5'-O-(2-thiodiphosphate) purinergic receptor P2Y12 Homo sapiens
8 Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). 2-Cl-ATP purinergic receptor P2Y12 Homo sapiens
9 Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). adenosine 5'-O-(3-thiotriphosphate) purinergic receptor P2Y12 Homo sapiens