Pub. Date : 2001 Mar 16
PMID : 11104774
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
2 | ADP was subsequently shown to inhibit forskolin-stimulated adenylyl cyclase activity through selective activation of SP1999 with an EC(50) of 60 nM. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
3 | ADP was subsequently shown to inhibit forskolin-stimulated adenylyl cyclase activity through selective activation of SP1999 with an EC(50) of 60 nM. | Colforsin | purinergic receptor P2Y12 | Homo sapiens |
4 | Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). | 2-methylthio-ATP | purinergic receptor P2Y12 | Homo sapiens |
5 | Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). | methylthio-ADP | purinergic receptor P2Y12 | Homo sapiens |
6 | Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
7 | Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). | adenosine 5'-O-(2-thiodiphosphate) | purinergic receptor P2Y12 | Homo sapiens |
8 | Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). | 2-Cl-ATP | purinergic receptor P2Y12 | Homo sapiens |
9 | Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). | adenosine 5'-O-(3-thiotriphosphate) | purinergic receptor P2Y12 | Homo sapiens |