Title : Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes.

Pub. Date : 2000 Dec

PMID : 11095583






1 Functional Relationships(s)
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1 In fourteen cDNA-expressed human P450 enzymes having measurable activities, CYP1A2, CYP2A6, CYP2E1, and CYP3A5 were highly active in catalyzing 5-FU formation at a tegafur concentration of 100 microM. Fluorouracil cytochrome P450 family 3 subfamily A member 5 Homo sapiens