Pub. Date : 2000 Nov 24
PMID : 10973968
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77. | Dinoprost | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 2 | Deletion of this motif or overexpression of a NUR77 dominant negative protein caused a complete loss of 20alpha-HSD promoter activation by PGF(2)alpha. | Prostaglandins F | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 3 | We also show that PGF(2)alpha induces a very rapid expression of NUR77 that binds to a distal response element located at -1599/-1606 but does not interact with another proximal putative NUR77 response element located downstream in the promoter. | Prostaglandins F | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 4 | We also show that PGF(2)alpha induces a very rapid expression of NUR77 that binds to a distal response element located at -1599/-1606 but does not interact with another proximal putative NUR77 response element located downstream in the promoter. | Prostaglandins F | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 5 | By using cyclosporin A and PGF(2)alpha treatment, we established that inhibition of NUR77 DNA binding in vivo prevents PGF(2)alpha induction of the 20alpha-HSD gene in the corpus luteum. | Cyclosporine | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 6 | By using cyclosporin A and PGF(2)alpha treatment, we established that inhibition of NUR77 DNA binding in vivo prevents PGF(2)alpha induction of the 20alpha-HSD gene in the corpus luteum. | Prostaglandins F | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 7 | By using cyclosporin A and PGF(2)alpha treatment, we established that inhibition of NUR77 DNA binding in vivo prevents PGF(2)alpha induction of the 20alpha-HSD gene in the corpus luteum. | Prostaglandins F | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |
| 8 | Taken together, our results demonstrate, for the first time, that PGF(2)alpha induces in the corpus luteum the expression of the nuclear orphan receptor and transcription factor, NUR77, which in turn leads to the transcriptional stimulation of 20alpha-HSD, triggering the decrease in serum progesterone essential for parturition. | Dinoprost | nuclear receptor subfamily 4, group A, member 1 | Mus musculus |