Pub. Date : 2000 Aug
PMID : 10930377
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gastrointestinal glutathione peroxidase prevents transport of lipid hydroperoxides in CaCo-2 cells. | Lipid Peroxides | glutathione peroxidase 2 | Homo sapiens |
| 2 | BACKGROUND & AIMS: Gastrointestinal glutathione peroxidase (GI-GPx), 1 of the 4 types of selenium-dependent glutathione peroxidases, is expressed exclusively in the gastrointestinal system and has therefore been suggested to function as a barrier against the absorption of dietary hydroperoxides. | Adenosine Monophosphate | glutathione peroxidase 2 | Homo sapiens |
| 3 | BACKGROUND & AIMS: Gastrointestinal glutathione peroxidase (GI-GPx), 1 of the 4 types of selenium-dependent glutathione peroxidases, is expressed exclusively in the gastrointestinal system and has therefore been suggested to function as a barrier against the absorption of dietary hydroperoxides. | Adenosine Monophosphate | glutathione peroxidase 2 | Homo sapiens |
| 4 | BACKGROUND & AIMS: Gastrointestinal glutathione peroxidase (GI-GPx), 1 of the 4 types of selenium-dependent glutathione peroxidases, is expressed exclusively in the gastrointestinal system and has therefore been suggested to function as a barrier against the absorption of dietary hydroperoxides. | Selenium | glutathione peroxidase 2 | Homo sapiens |
| 5 | BACKGROUND & AIMS: Gastrointestinal glutathione peroxidase (GI-GPx), 1 of the 4 types of selenium-dependent glutathione peroxidases, is expressed exclusively in the gastrointestinal system and has therefore been suggested to function as a barrier against the absorption of dietary hydroperoxides. | Selenium | glutathione peroxidase 2 | Homo sapiens |
| 6 | BACKGROUND & AIMS: Gastrointestinal glutathione peroxidase (GI-GPx), 1 of the 4 types of selenium-dependent glutathione peroxidases, is expressed exclusively in the gastrointestinal system and has therefore been suggested to function as a barrier against the absorption of dietary hydroperoxides. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |
| 7 | BACKGROUND & AIMS: Gastrointestinal glutathione peroxidase (GI-GPx), 1 of the 4 types of selenium-dependent glutathione peroxidases, is expressed exclusively in the gastrointestinal system and has therefore been suggested to function as a barrier against the absorption of dietary hydroperoxides. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |
| 8 | METHODS: The selenium-dependent expression of GI-GPx and cytosolic GPx (cGPx) was analyzed by Western blotting. | Selenium | glutathione peroxidase 2 | Homo sapiens |
| 9 | Transport of 13-hydroperoxy octadecadienoic acid (13-HPODE) was investigated in a CaCo-2 cell monolayer modulated in GI-GPx and cGPx by selenium restriction or repletion. | 13-hydroperoxy octadecadienoic acid | glutathione peroxidase 2 | Homo sapiens |
| 10 | Transport of 13-hydroperoxy octadecadienoic acid (13-HPODE) was investigated in a CaCo-2 cell monolayer modulated in GI-GPx and cGPx by selenium restriction or repletion. | 13-Hpode | glutathione peroxidase 2 | Homo sapiens |
| 11 | RESULTS: Low but significant GI-GPx levels were detected in selenium-deficient CaCo-2 cells and in the gastrointestinal tract of selenium-deficient rats, whereas cGPx was completely absent. | Selenium | glutathione peroxidase 2 | Homo sapiens |
| 12 | RESULTS: Low but significant GI-GPx levels were detected in selenium-deficient CaCo-2 cells and in the gastrointestinal tract of selenium-deficient rats, whereas cGPx was completely absent. | Selenium | glutathione peroxidase 2 | Homo sapiens |
| 13 | Selenium supplementation of CaCo-2 cells resulted in a 5-fold increase of GI-GPx protein, whereas total GPx activity increased by a factor of 13, with most of the GPx activity under selenium-adequate conditions being cGPx. | Selenium | glutathione peroxidase 2 | Homo sapiens |
| 14 | CONCLUSIONS: Low GI-GPx levels, as present in selenium deficiency, suffice to prevent transport of 13-HPODE. | Selenium | glutathione peroxidase 2 | Homo sapiens |
| 15 | GI-GPx may thus function as a barrier against hydroperoxide absorption. | Hydrogen Peroxide | glutathione peroxidase 2 | Homo sapiens |