Pub. Date : 2000 Aug
PMID : 10901692
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The apparent Michaelis-Menten Km values for DDS-NHY by cloned CYP2C8, CYP2C9, CYP2C18, and CYP2C19 were 75 microM, 31 microM, 25 microM, and greater than 1 mM, respectively. | Fumigant 93 | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 2 | In contrast, S-mephenytoin inhibited DDS-NHY by CYP2C9, CYP2C18, and CYP2C19 by 27 +/- 2, 49 +/- 1, and 32 +/- 4%, respectively. | Mephenytoin | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 3 | In contrast, S-mephenytoin inhibited DDS-NHY by CYP2C9, CYP2C18, and CYP2C19 by 27 +/- 2, 49 +/- 1, and 32 +/- 4%, respectively. | Fumigant 93 | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 4 | Because CYP2C18 and CYP19 are expressed at low concentrations in the human liver, these observations indicate that at clinical DDS concentrations, CYP2C9 is a major and CYP2C8 is a likely minor contributor to DDS-NHY in human liver microsomes. | Fumigant 93 | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |
| 5 | Because CYP2C18 and CYP19 are expressed at low concentrations in the human liver, these observations indicate that at clinical DDS concentrations, CYP2C9 is a major and CYP2C8 is a likely minor contributor to DDS-NHY in human liver microsomes. | Fumigant 93 | cytochrome P450 family 2 subfamily C member 18 | Homo sapiens |