Title : Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences.

Pub. Date : 2000 Jul 18

PMID : 10890888






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences. 8-hydroxyguanine 8-oxoguanine DNA-glycosylase 1 Mus musculus
2 To assess the role of the Ogg1 DNA glycosylase in the transcription-coupled repair (TCR) of the mutagenic lesion, 7, 8-dihydro-8oxoguanine (8-OxoG), we have investigated the removal of this lesion in wild-type and ogg1(-/-) null mouse embryo fibroblast (MEF) cell lines. 7,8-dihydro-8-oxoguanine 8-oxoguanine DNA-glycosylase 1 Mus musculus
3 Therefore, we have demonstrated that Ogg1 is essential for the repair of 8-OxoG in the NTS but is not required in the TS. nts 8-oxoguanine DNA-glycosylase 1 Mus musculus