Title : Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.

Pub. Date : 2000 Jun

PMID : 10820137






1 Functional Relationships(s)
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1 Intravenous administration of the novel and potent P-glycoprotein inhibitor LY-335979 to mice (1-50 mg/kg) increased brain and testes concentration of [(14)C]nelfinavir, up to 37- and 4-fold, respectively, in a dose-dependent fashion. Nelfinavir ATP binding cassette subfamily B member 1 Homo sapiens