Title : The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria.

Pub. Date : 2000 May 19

PMID : 10818227






2 Functional Relationships(s)
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1 RIP3-mediated apoptosis was inhibited by Bcl-2, Bcl-x(L), dominant-negative FADD, as well as the general caspase inhibitor Z-VAD. z-vad receptor interacting serine/threonine kinase 3 Homo sapiens
2 Further dissection of caspase involvement in RIP3-induced apoptosis indicated inhibition by the more specific inhibitors Z-DEVD (caspase-3, -6, -7, -8, and -10) and Z-VDVAD (caspase-2). z-devd receptor interacting serine/threonine kinase 3 Homo sapiens