PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10799656-1	2000	Mitochondrial thymidine kinase (TK2) phosphorylates pyrimidine nucleosides to monophosphates and is expressed constitutively through the cell cycle in all cells.	Pyrimidine Nucleosides	52-74	thymidine kinase 2	Homo sapiens	32-35	
10799656-1	2000	Mitochondrial thymidine kinase (TK2) phosphorylates pyrimidine nucleosides to monophosphates and is expressed constitutively through the cell cycle in all cells.	monophosphates	78-92	thymidine kinase 2	Homo sapiens	32-35	
10799656-2	2000	Because of the overlap of its substrate specificity with that of the cytosolic thymidine kinase (TK1) and deoxycytidine kinase (dCK), it has been difficult to determine the role of TK2 in activating nucleosides used in chemotherapy.	Nucleosides	199-210	thymidine kinase 2	Homo sapiens	181-184	
10799656-3	2000	In this report, we described the construction of a recombinant Escherichia coli strain which could be used to test if TK2 activity is limiting for the toxicity of nucleosides.	Nucleosides	163-174	thymidine kinase 2	Homo sapiens	118-121	
10799656-4	2000	Enzymes of bacterial origin which are involved in thymidine and deoxyuridine anabolism and catabolism were eliminated, and the cDNA for human TK2 was introduced.	Thymidine	50-59	thymidine kinase 2	Homo sapiens	142-145	
10799656-4	2000	Enzymes of bacterial origin which are involved in thymidine and deoxyuridine anabolism and catabolism were eliminated, and the cDNA for human TK2 was introduced.	Deoxyuridine	64-76	thymidine kinase 2	Homo sapiens	142-145	
10799656-9	2000	These results demonstrate that activation of growth-inhibiting pyrimidine nucleosides can be catalyzed by TK2, and together with recombinant E. coli strains expressing other cellular nucleoside kinases, this whole-cell bacterial system may serve as a tool to predict the efficacy and side effects of chemotherapeutic nucleosides.	Pyrimidine Nucleosides	63-85	thymidine kinase 2	Homo sapiens	106-109	
10799656-9	2000	These results demonstrate that activation of growth-inhibiting pyrimidine nucleosides can be catalyzed by TK2, and together with recombinant E. coli strains expressing other cellular nucleoside kinases, this whole-cell bacterial system may serve as a tool to predict the efficacy and side effects of chemotherapeutic nucleosides.	Nucleosides	74-85	thymidine kinase 2	Homo sapiens	106-109