Title : Alcohol up-regulates UDP-glucuronosyltransferase mRNA expression in rat liver and in primary rat hepatocyte culture.

Pub. Date : 2000

PMID : 10794513






7 Functional Relationships(s)
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1 In cultured hepatocytes, treatment with either ethanol or isopentanol significantly increased the expression of UGT1A1, UGT1A5, UGT2B1, and UGT2B3 mRNAs, but to different degrees. isopentyl alcohol UDP glucuronosyltransferase family 1 member A1 Rattus norvegicus
2 In cultured hepatocytes, treatment with either ethanol or isopentanol significantly increased the expression of UGT1A1, UGT1A5, UGT2B1, and UGT2B3 mRNAs, but to different degrees. isopentyl alcohol UDP glucuronosyltransferase family 1 member A5 Rattus norvegicus
3 In cultured hepatocytes, treatment with either ethanol or isopentanol significantly increased the expression of UGT1A1, UGT1A5, UGT2B1, and UGT2B3 mRNAs, but to different degrees. isopentyl alcohol UDP glucuronosyltransferase family 2 member B17 Rattus norvegicus
4 In cultured hepatocytes, treatment with either ethanol or isopentanol significantly increased the expression of UGT1A1, UGT1A5, UGT2B1, and UGT2B3 mRNAs, but to different degrees. isopentyl alcohol UDP glucuronosyltransferase family 2 member B15 Rattus norvegicus
5 The induction of UGT1A1 and UGT2B1 mRNAs by ethanol or isopentanol was time-dependent and maximal changes occurred at 48 h. The expression of UGT1A6 mRNA was not significantly modified by either ethanol or isopentanol. isopentyl alcohol UDP glucuronosyltransferase family 1 member A1 Rattus norvegicus
6 The induction of UGT1A1 and UGT2B1 mRNAs by ethanol or isopentanol was time-dependent and maximal changes occurred at 48 h. The expression of UGT1A6 mRNA was not significantly modified by either ethanol or isopentanol. isopentyl alcohol UDP glucuronosyltransferase family 2 member B17 Rattus norvegicus
7 The induction of UGT1A1 and UGT2B1 mRNAs by ethanol or isopentanol was time-dependent and maximal changes occurred at 48 h. The expression of UGT1A6 mRNA was not significantly modified by either ethanol or isopentanol. isopentyl alcohol UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus