Protein Name UDP glucuronosyltransferase family 1 member A1
Organism Rattus norvegicus
Gene ID 24861
Gene Symbol

Ugt1a1

UniProt Q64550 (UD11_RAT), Q5DT04 (Q5DT04_RAT)
Relationships Total Number of functionally related compound(s) : 211
Total Number of Articles : 193
Description

UDP glucuronosyltransferase family 1 member A1

Gene Summary

Enables enzyme binding activity and glucuronosyltransferase activity. Involved in several processes, including biphenyl catabolic process; cellular glucuronidation; and cellular response to lipid. Located in endoplasmic reticulum. Part of cytochrome complex. Used to study Crigler-Najjar syndrome and bilirubin metabolic disorder. Biomarker of hyperthyroidism; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; female reproductive organ cancer (multiple); and hepatitis B. Orthologous to human UGT1A1 (UDP glucuronosyltransferase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • UDP-glucuronosyltransferase 1A1
  • B1
  • UDP glucuronosyltransferase 1 family, polypeptide A1
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Properties