Protein Name | UDP glucuronosyltransferase family 1 member A1 |
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Organism | Rattus norvegicus |
Gene ID | 24861 |
Gene Symbol | Ugt1a1 |
UniProt | Q64550 (UD11_RAT), Q5DT04 (Q5DT04_RAT) |
Relationships |
Total Number of functionally related compound(s) :
211
Total Number of Articles : 193 |
Description |
UDP glucuronosyltransferase family 1 member A1 |
Gene Summary |
Enables enzyme binding activity and glucuronosyltransferase activity. Involved in several processes, including biphenyl catabolic process; cellular glucuronidation; and cellular response to lipid. Located in endoplasmic reticulum. Part of cytochrome complex. Used to study Crigler-Najjar syndrome and bilirubin metabolic disorder. Biomarker of hyperthyroidism; type 1 diabetes mellitus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including bilirubin metabolic disorder (multiple); cholecystolithiasis; cholelithiasis; female reproductive organ cancer (multiple); and hepatitis B. Orthologous to human UGT1A1 (UDP glucuronosyltransferase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022] |
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