Pub. Date : 2000 Apr
PMID : 10778948
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of an individual"s cytochrome CYP3A4 activity on docetaxel clearance. | Docetaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Docetaxel undergoes metabolism by cytochrome CYP3A4. | Docetaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Patients with low CYP3A4 activity are at risk for having decreased CL and may thus experience increased toxicity from docetaxel. | Docetaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | By measuring CYP3A4 activity, the ERMBT may be clinically useful in tailoring doses of CYP3A4 substrates, such as docetaxel, in certain individuals. | Docetaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | By measuring CYP3A4 activity, the ERMBT may be clinically useful in tailoring doses of CYP3A4 substrates, such as docetaxel, in certain individuals. | Docetaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |