Title : A concise synthesis of physostigmine from skatole and activated aziridine via alkylative cyclization.

Pub. Date : 2000 Apr 6

PMID : 10768195






3 Functional Relationships(s)
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1 A concise synthetic route to physostigmine has been developed, where the key step relies on the alkylative cyclization of 1,3-dimethylindole with (Z)-aziridine catalyzed by Sc(OTf)3 and TMSCI in dichloromethane at -30 degrees C, to give 8 in 90% yield, which, in turn, can be readily converted into physostigmine. Physostigmine POU class 5 homeobox 1 Homo sapiens
2 A concise synthetic route to physostigmine has been developed, where the key step relies on the alkylative cyclization of 1,3-dimethylindole with (Z)-aziridine catalyzed by Sc(OTf)3 and TMSCI in dichloromethane at -30 degrees C, to give 8 in 90% yield, which, in turn, can be readily converted into physostigmine. 1,3-Dimethylindole POU class 5 homeobox 1 Homo sapiens
3 A concise synthetic route to physostigmine has been developed, where the key step relies on the alkylative cyclization of 1,3-dimethylindole with (Z)-aziridine catalyzed by Sc(OTf)3 and TMSCI in dichloromethane at -30 degrees C, to give 8 in 90% yield, which, in turn, can be readily converted into physostigmine. (z)-aziridine POU class 5 homeobox 1 Homo sapiens