Protein Name POU class 5 homeobox 1
Organism Homo sapiens
Gene ID 5460
Gene Symbol


UniProt Q01860 (PO5F1_HUMAN), M1S623 (M1S623_HUMAN), F2Z381 (F2Z381_HUMAN), D2IYK3 (D2IYK3_HUMAN)
Relationships Total Number of functionally related compound(s) : 1245
Total Number of Articles : 1038

POU class 5 homeobox 1

Gene Summary

This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

  • POU domain, class 5, transcription factor 1
  • POU domain transcription factor OCT4
  • POU-type homeodomain-containing DNA-binding protein
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