Pub. Date : 2000 Jun 2
PMID : 10748048
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Plasma and tissue levels of 25- and 27-hydroxycholesterol, two oxysterol substrates of this enzyme with potent regulatory actions in cultured cells, were markedly elevated in Cyp7b1(-/-) knockout animals. | Hydroxycholesterols | cytochrome P450, family 7, subfamily b, polypeptide 1 | Mus musculus |
| 2 | Plasma and tissue levels of 25- and 27-hydroxycholesterol, two oxysterol substrates of this enzyme with potent regulatory actions in cultured cells, were markedly elevated in Cyp7b1(-/-) knockout animals. | Oxysterols | cytochrome P450, family 7, subfamily b, polypeptide 1 | Mus musculus |
| 3 | We conclude that the major physiological role of the CYP7B1 oxysterol 7alpha-hydroxylase is to metabolize 25- and 27-hydroxycholesterol and that loss of this enzyme in the liver is compensated for by increases in the synthesis of bile acids by other pathways. | 25- and 27-hydroxycholesterol | cytochrome P450, family 7, subfamily b, polypeptide 1 | Mus musculus |
| 4 | We conclude that the major physiological role of the CYP7B1 oxysterol 7alpha-hydroxylase is to metabolize 25- and 27-hydroxycholesterol and that loss of this enzyme in the liver is compensated for by increases in the synthesis of bile acids by other pathways. | 25- and 27-hydroxycholesterol | cytochrome P450, family 7, subfamily b, polypeptide 1 | Mus musculus |
| 5 | We conclude that the major physiological role of the CYP7B1 oxysterol 7alpha-hydroxylase is to metabolize 25- and 27-hydroxycholesterol and that loss of this enzyme in the liver is compensated for by increases in the synthesis of bile acids by other pathways. | Bile Acids and Salts | cytochrome P450, family 7, subfamily b, polypeptide 1 | Mus musculus |
| 6 | We conclude that the major physiological role of the CYP7B1 oxysterol 7alpha-hydroxylase is to metabolize 25- and 27-hydroxycholesterol and that loss of this enzyme in the liver is compensated for by increases in the synthesis of bile acids by other pathways. | Bile Acids and Salts | cytochrome P450, family 7, subfamily b, polypeptide 1 | Mus musculus |