Title : Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives.

Pub. Date : 2000 Jan 27

PMID : 10649978






1 Functional Relationships(s)
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1 Interestingly, the impact of the hydroxylated analogues on ornithine decarboxylase (ODC) was significantly less than that of unhydroxylated parent drug (e.g., N(1),N(11)-diethylnorspermine [DENSPM]) at 1 microM; however, S-adenosylmethionine decarboxylase (AdoMetDC) depletion was nearly identical to what was observed in cells treated with parent drug. N(1),N(11)-diethylnorspermine ornithine decarboxylase, structural 1 Mus musculus