Pub. Date : 1999 Sep 1
PMID : 10485486
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. | Caffeine | ATR serine/threonine kinase | Homo sapiens |
| 2 | We now show that caffeine inhibits the catalytic activity of both ATM and the related kinase, ATM and Rad3-related (ATR), at drug concentrations similar to those that induce radiosensitization. | Caffeine | ATR serine/threonine kinase | Homo sapiens |
| 3 | Similar concentrations of caffeine also inhibit gamma- and UV radiation-induced phosphorylation of p53 on Ser15, a modification that may be directly mediated by the ATM and ATR kinases. | Caffeine | ATR serine/threonine kinase | Homo sapiens |
| 4 | These data suggest that the radiosensitizing effects of caffeine are related to inhibition of the protein kinase activities of ATM and ATR and that both proteins are relevant targets for the development of novel anticancer agents. | Caffeine | ATR serine/threonine kinase | Homo sapiens |