Title : Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.

Pub. Date : 1999 Aug

PMID : 10421786






1 Functional Relationships(s)
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1 However, disruption of a membrane-proximal proline-rich sequence motif ("box1") in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation. Proline Janus kinase 1 Mus musculus