Title : PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway.

Pub. Date : 1999 Jul 16

PMID : 10400703






3 Functional Relationships(s)
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Protein Name
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1 PTEN dephosphorylates phosphatidylinositol 3,4, 5-trisphosphate (PIP3) and focal adhesion kinase (FAK), and it can inhibit cell growth, invasion, migration, and focal adhesions. phosphatidylinositol 3,4,5-triphosphate phosphatase and tensin homolog Homo sapiens
2 PTEN dephosphorylates phosphatidylinositol 3,4, 5-trisphosphate (PIP3) and focal adhesion kinase (FAK), and it can inhibit cell growth, invasion, migration, and focal adhesions. PIP3 phosphatase and tensin homolog Homo sapiens
3 PTEN-mutated cells were resistant to apoptosis in suspension, but most of the cells entered apoptosis after expression of exogenous PTEN or wortmannin treatment. Wortmannin phosphatase and tensin homolog Homo sapiens