Pub. Date : 1999 Apr
PMID : 10385214
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5. | halofantrine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | The rate of formation of N-debutylhalofantrine was six- and twelvefold with CYP 3A4 than with CYP 3A5 and CYP 2C8, respectively. | 1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | These results indicate that both CYP 3A4 and CYP 3A5 metabolize halofantrine, with major involvement of CYP 3A4. | halofantrine | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |