Title : Assay of procarboxypeptidase U, a novel determinant of the fibrinolytic cascade, in human plasma.

Pub. Date : 1999 Jun

PMID : 10351989






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The active form, carboxypeptidase U (CPU; EC 3.4.17.20), retards the rate of fibrinolysis through its ability to cleave C-terminal lysine residues on fibrin partially degraded by plasmin. Lysine carboxypeptidase B2 Homo sapiens
2 The active form, carboxypeptidase U (CPU; EC 3.4.17.20), retards the rate of fibrinolysis through its ability to cleave C-terminal lysine residues on fibrin partially degraded by plasmin. Lysine carboxypeptidase B2 Homo sapiens
3 The assay involved quantitative conversion of proCPU to active CPU by thrombin-thrombomodulin, a very efficient activator of proCPU, followed by determination of the enzymatic activity of CPU with the substrate hippuryl-L-arginine, using an HPLC-assisted determination of the released hippuric acid. hippuryl-L-arginine carboxypeptidase B2 Homo sapiens