Title : Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases.

Pub. Date : 1999

PMID : 10336074






5 Functional Relationships(s)
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1 In this situation, the activity of caspase-3-like proteinases was elevated, and the survival rate could be maintained by treatment with acetyl-DEVD-cho, a specific inhibitor of caspase-3. acetyl-devd-cho caspase 3 Rattus norvegicus
2 In this situation, the activity of caspase-3-like proteinases was elevated, and the survival rate could be maintained by treatment with acetyl-DEVD-cho, a specific inhibitor of caspase-3. acetyl-devd-cho caspase 3 Rattus norvegicus
3 In a culture of PC12 cells treated with acetyl-DEVD-cho, where caspase-3-like proteinases are not activated, CA074, a specific inhibitor of cathepsin B induced active death of the cells. acetyl-devd-cho caspase 3 Rattus norvegicus
4 By double staining of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end-labeling and activated caspase-3, the dying cells treated with CA074 were positive for terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end-labeling staining but negative for activated caspase-3. N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline caspase 3 Rattus norvegicus
5 By double staining of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end-labeling and activated caspase-3, the dying cells treated with CA074 were positive for terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end-labeling staining but negative for activated caspase-3. N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline caspase 3 Rattus norvegicus