Title : Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): a strategy for vascular immunotargeting of drugs.

Pub. Date : 1999 Mar 2

PMID : 10051650






3 Functional Relationships(s)
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Protein Name
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1 In addition, conjugation with streptavidin markedly stimulated uptake of 125I-labeled b-anti-PECAM in perfused rat lungs and in the lungs of intact animals after either intravenous or intraarterial injection. Iodine-125 platelet and endothelial cell adhesion molecule 1 Rattus norvegicus
2 The antioxidant enzyme catalase conjugated with b-anti-PECAM/SA bound to endothelial cells in culture, entered the cells, escaped intracellular degradation, and protected the cells against H2O2-induced injury. Hydrogen Peroxide platelet and endothelial cell adhesion molecule 1 Rattus norvegicus
3 Anti-PECAM/SA/125I-catalase accumulated in the lungs after intravenous injection or in the perfused rat lungs and protected these lungs against H2O2-induced injury. Hydrogen Peroxide platelet and endothelial cell adhesion molecule 1 Rattus norvegicus