Pub. Date : 1999 Mar 2
PMID : 10051603
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A PTEN mutant associated with Cowden"s disease (PTEN;G129E) has protein phosphatase activity yet is defective in dephosphorylating inositol 1,3,4,5-tetrakisphosphate in vitro and fails to arrest cells in G1. | inositol-1,3,4,5-tetrakisphosphate | phosphatase and tensin homolog | Homo sapiens |
| 2 | A PTEN mutant associated with Cowden"s disease (PTEN;G129E) has protein phosphatase activity yet is defective in dephosphorylating inositol 1,3,4,5-tetrakisphosphate in vitro and fails to arrest cells in G1. | inositol-1,3,4,5-tetrakisphosphate | phosphatase and tensin homolog | Homo sapiens |
| 3 | These data suggest a link between induction of a cell-cycle block by PTEN and its ability to dephosphorylate, in vivo, phosphatidylinositol 3,4,5-trisphosphate. | phosphatidylinositol 3,4,5-triphosphate | phosphatase and tensin homolog | Homo sapiens |
| 4 | In keeping with this notion, PTEN can inhibit the phosphatidylinositol 3,4, 5-trisphosphate-dependent Akt kinase, a downstream target of phosphatidylinositol 3-kinase, and constitutively active, but not wild-type, Akt overrides a PTEN G1 arrest. | Phosphatidylinositols | phosphatase and tensin homolog | Homo sapiens |
| 5 | In keeping with this notion, PTEN can inhibit the phosphatidylinositol 3,4, 5-trisphosphate-dependent Akt kinase, a downstream target of phosphatidylinositol 3-kinase, and constitutively active, but not wild-type, Akt overrides a PTEN G1 arrest. | Phosphatidylinositols | phosphatase and tensin homolog | Homo sapiens |