Title : Effect of the chlorinated hydrocarbons heptachlor, chlordane, and toxaphene on retinoblastoma tumor suppressor in human lymphocytes.

Pub. Date : 1999 Jan 11

PMID : 10048758






3 Functional Relationships(s)
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1 In this study, experiments with CEM x 174 cells, a hybrid of human T and B cells, were performed to investigate the effects of the tumor promoter heptachlor and its congeners chlordane and toxaphene on retinoblastoma (Rb) gene expression. Heptachlor RB transcriptional corepressor 1 Homo sapiens
2 In this study, experiments with CEM x 174 cells, a hybrid of human T and B cells, were performed to investigate the effects of the tumor promoter heptachlor and its congeners chlordane and toxaphene on retinoblastoma (Rb) gene expression. Heptachlor RB transcriptional corepressor 1 Homo sapiens
3 The results indicated that heptachlor, chlordane or toxaphene, in the range of 10-50 microM, were able to reduce Rb protein levels in a concentration-dependent manner. Heptachlor RB transcriptional corepressor 1 Homo sapiens