Protein Name RB transcriptional corepressor 1
Organism Homo sapiens
Gene ID 5925
Gene Symbol


UniProt P06400 (RB_HUMAN), A0A024RDV3 (A0A024RDV3_HUMAN)
Relationships Total Number of functionally related compound(s) : 809
Total Number of Articles : 1281

RB transcriptional corepressor 1

Gene Summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

  • retinoblastoma-associated protein
  • prepro-retinoblastoma-associated protein
  • protein phosphatase 1, regulatory subunit 130
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