Title : Elevated expression of the CD4 receptor and cell cycle arrest are induced in Jurkat cells by treatment with the novel cyclic dinucleotide 3',5'-cyclic diguanylic acid.

Pub. Date : 1999 Feb 5

PMID : 10037160






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 When exposed to 50 microM c-di-GMP, Jurkat cells exhibited a markedly elevated expression of the CD4 receptor of up to 6.3-fold over controls. bis(3',5')-cyclic diguanylic acid CD4 molecule Homo sapiens
2 Additionally c-di-GMP naturally enters these cells and binds irreversibly to the P21ras protein. bis(3',5')-cyclic diguanylic acid HRas proto-oncogene, GTPase Homo sapiens