Title : Protein kinase A anchoring proteins are required for vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.

Pub. Date : 1999 Feb 19

PMID : 9988736






2 Functional Relationships(s)
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1 The antidiuretic hormone arginine-vasopressin (AVP) regulates water reabsorption in renal collecting duct principal cells by inducing a cAMP-dependent translocation of water channels (aquaporin-2, AQP-2) from intracellular vesicles into the apical cell membranes. Cyclic AMP aquaporin 2 Rattus norvegicus
2 These data demonstrate that not only the activity of PKA, but also its tethering to subcellular compartments, are prerequisites for cAMP-dependent AQP-2 translocation. Cyclic AMP aquaporin 2 Rattus norvegicus