Protein Name aquaporin 2
Organism Rattus norvegicus
Gene ID 25386
Gene Symbol


UniProt P34080 (AQP2_RAT)
Relationships Total Number of functionally related compound(s) : 198
Total Number of Articles : 345

aquaporin 2

Gene Summary

Enables PDZ domain binding activity; actin binding activity; and water transmembrane transporter activity. Involved in several processes, including actin filament depolymerization; cellular response to water deprivation; and response to glucagon. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and trans-Golgi network. Part of protein-containing complex. Used to study diabetes insipidus. Biomarker of hypertension and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus. Orthologous to human AQP2 (aquaporin 2). [provided by Alliance of Genome Resources, Apr 2022]

  • aquaporin-2
  • ADH water channel
  • AQP-CD
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