Title : The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells.

Pub. Date : 1999 Feb 15

PMID : 9973505






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 SZP or beta-glucans primed CR3 of neutrophils, macrophages, and NK cells for cytotoxicity of iC3b-opsonized tumor cells that otherwise did not trigger killing. beta-Glucans integrin alpha M Mus musculus
2 beta-Glucan priming for cytotoxicity was inhibited by anti-CR3 and did not occur with leukocytes from CR3-/- mice. beta-Glucans integrin alpha M Mus musculus
3 The primed state of macrophage and NK cell CR3 remained detectable for 18 to 24 h after pulsing with beta-glucans. beta-Glucans integrin alpha M Mus musculus