Protein Name integrin alpha M
Organism Mus musculus
Gene ID 16409
Gene Symbol

Itgam

UniProt E9Q604 (E9Q604_MOUSE), G5E8F1 (G5E8F1_MOUSE)
Relationships Total Number of functionally related compound(s) : 525
Total Number of Articles : 654
Description

integrin alpha M

Gene Summary

Enables complement component C3b binding activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Contributes to cargo receptor activity. Involved in several processes, including central nervous system development; endocytosis; and positive regulation of neuron death. Acts upstream of or within several processes, including activated T cell proliferation; leukocyte migration; and microglia development. Located in external side of plasma membrane and nucleus. Is integral component of membrane. Part of integrin alphaM-beta2 complex. Is expressed in several structures, including central nervous system; heart; lymphatic vessel; thymus; and yolk sac. Human ortholog(s) of this gene implicated in lupus nephritis. Orthologous to human ITGAM (integrin subunit alpha M). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • integrin alpha-M
  • CD11 antigen-like family member B
  • CD11B (p170)
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Properties