Pub. Date : 1999 Feb 12
PMID : 9933579
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In contrast, Bcr-Abl-negative HL60 myeloid leukemia cells, which are sensitive to taxol-induced apoptosis, do not exhibit sustained PKCiota activation in response to taxol. | Paclitaxel | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Treatment of K562 cells with tyrphostin AG957, a selective Bcr-Abl inhibitor, blocks taxol-induced PKCiota activation and sensitizes these cells to taxol-induced apoptosis, indicating that PKCiota is a relevant downstream target of Bcr-Abl-mediated resistance. | Paclitaxel | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Treatment of K562 cells with tyrphostin AG957, a selective Bcr-Abl inhibitor, blocks taxol-induced PKCiota activation and sensitizes these cells to taxol-induced apoptosis, indicating that PKCiota is a relevant downstream target of Bcr-Abl-mediated resistance. | Paclitaxel | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |