Title : N-terminal elongation of a peptide determinant beyond the first primary anchor improves binding to H-2 I-Ad and HLA-DR1 by backbone-dependent and aromatic side chain-dependent interactions, respectively.

Pub. Date : 1999 Jan

PMID : 9933100






1 Functional Relationships(s)
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1 The interaction between HLA-DR1 and P-3 specifically required an aromatic peptide side chain, and computer simulations indicated that the aromatic ring at P-3 engaged conserved HLA-DR1 phenylalanine residues at the edge of the peptide binding groove. Phenylalanine ATP synthase membrane subunit c locus 3 Homo sapiens