Protein Name ATP synthase membrane subunit c locus 3
Organism Homo sapiens
Gene ID 518
Gene Symbol

ATP5MC3

UniProt P48201 (AT5G3_HUMAN)
Relationships Total Number of functionally related compound(s) : 13
Total Number of Articles : 7
Description

ATP synthase membrane subunit c locus 3

Gene Summary

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified. [provided by RefSeq, Jun 2010]

synonyms
  • ATP synthase F(0) complex subunit C3, mitochondrial
  • ATP synthase lipid-binding protein, mitochondrial
  • ATP synthase proteolipid P3
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Properties