Title : Dehydroepiandrosterone: biosynthesis and metabolism in the brain.

Pub. Date : 1999 Feb

PMID : 9927319






2 Functional Relationships(s)
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1 The presence of P450c17 in astrocytes and neurons was supported by the ability of these cells to metabolize pregnenolone to DHEA in a dose-dependent manner as determined by RIA. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 These data suggest that as in gonads and adrenal, DHEA is biosynthesized in the brain by a P450c17-dependent mechanism. Dehydroepiandrosterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens