Title : In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes.

Pub. Date : 1999 Mar

PMID : 9925971






1 Functional Relationships(s)
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1 For formation of M2, both a rabbit CYP3A polyclonal antibody (110 microliter/mg microsomal protein) and ketoconazole (2 micromol/l), a CYP3A inhibitor, showed about 50% inhibitory effects; other specific inhibitors of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP2E1 showed no significant effects. Ketoconazole cytochrome P450 family 2 subfamily C member 9 Homo sapiens