Title : Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway.

Pub. Date : 1999 Jan 29

PMID : 9915817






1 Functional Relationships(s)
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1 Inhibition of MAPK kinase with PD98059, PI 3-kinase with wortmannin, and p38 MAPK with SB203580 blocked IGF-I-mediated phosphorylation and transcriptional activation of CREB by 30-50% (p < 0.001). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one insulin-like growth factor 1 Rattus norvegicus