Pub. Date : 1998 Aug-Nov
PMID : 9888582
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Human P450c17 catalyzes the 17alpha-hydroxylation of pregnenolone to 17OH pregnenolone and of progesterone to 17alpha-OH progesterone; the same P450c17 enzyme also catalyzes 17,20 lyase activity on the same active site, converting 17OH-pregnenolone to DHEA. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Human P450c17 catalyzes the 17alpha-hydroxylation of pregnenolone to 17OH pregnenolone and of progesterone to 17alpha-OH progesterone; the same P450c17 enzyme also catalyzes 17,20 lyase activity on the same active site, converting 17OH-pregnenolone to DHEA. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 4 | Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. | Dehydroepiandrosterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |