Pub. Date : 1999 Jan
PMID : 9886920
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differing temporal roles of Ca2+ and cAMP in nicotine-elicited elevation of tyrosine hydroxylase mRNA. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 2 | The involvement of cAMP- and Ca2+-mediated pathways in the activation of tyrosine hydroxylase (TH) gene expression by nicotine was examined in PC-12 cells. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 3 | The involvement of cAMP- and Ca2+-mediated pathways in the activation of tyrosine hydroxylase (TH) gene expression by nicotine was examined in PC-12 cells. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 4 | Extracellular Ca2+ and elevations in intracellular Ca2+ concentration ([Ca2+]i) were required for nicotine to increase TH mRNA. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 5 | DDA also blocked the elevation of TH mRNA only when added after the initial transient rise in [Ca2+]i and not after 1 h. This study reveals that several temporal phases are involved in the induction of TH gene expression by nicotine, each of them with differing requirements for Ca2+ and cAMP. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |
| 6 | DDA also blocked the elevation of TH mRNA only when added after the initial transient rise in [Ca2+]i and not after 1 h. This study reveals that several temporal phases are involved in the induction of TH gene expression by nicotine, each of them with differing requirements for Ca2+ and cAMP. | Nicotine | tyrosine hydroxylase | Rattus norvegicus |