Title : Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation.

Pub. Date : 1999 Jan 15

PMID : 9885231






1 Functional Relationships(s)
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1 In the present study, we investigated the mechanism by which sphingosine and its analogues, dihydrosphingosine and phytosphingosine, inhibit polymorphonuclear leukocyte (PMN) phagocytosis of IgG-opsonized erythrocytes (EIgG) and inhibit ERK1 and ERK2 phosphorylation. phytosphingosine mitogen-activated protein kinase 3 Homo sapiens