Title : Studies of the role of the integrin EF-hand, Ca2+-binding sites in glycosylphosphatidylinositol-specific phospholipase D: reduced expression following mutagenesis of residues predicted to bind Ca2+.

Pub. Date : 1999 Jan 1

PMID : 9882439






1 Functional Relationships(s)
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1 The enzymatic activity of purified GPI-PLD, which was depleted of divalent cations by pretreatment with EDTA, EGTA, or 1, 10-phenanthroline, could be completely restored with Zn2+ (and partially with Co2+), which indicates that Ca2+ can be removed from the protein without affecting its enzymatic activity. 1,10-phenanthroline glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens