Title : S-adenosylmethionine decarboxylase activity and utilization of exogenous putrescine are enhanced in colon cancer cells stimulated to grow by EGF.

Pub. Date : 1998 Nov

PMID : 9880821






6 Functional Relationships(s)
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1 S-adenosylmethionine decarboxylase activity and utilization of exogenous putrescine are enhanced in colon cancer cells stimulated to grow by EGF. Putrescine epidermal growth factor Homo sapiens
2 AIMS: To investigate the utilization of luminal putrescine in colon cancer, we studied the effect of a potent mitogen, epidermal growth factor (EGF), on the activity of the enzyme responsible for putrescine conversion, S-adenosylmethionine decarboxylase (SAMDC), in Caco-2 cells. Putrescine epidermal growth factor Homo sapiens
3 AIMS: To investigate the utilization of luminal putrescine in colon cancer, we studied the effect of a potent mitogen, epidermal growth factor (EGF), on the activity of the enzyme responsible for putrescine conversion, S-adenosylmethionine decarboxylase (SAMDC), in Caco-2 cells. Putrescine epidermal growth factor Homo sapiens
4 AIMS: To investigate the utilization of luminal putrescine in colon cancer, we studied the effect of a potent mitogen, epidermal growth factor (EGF), on the activity of the enzyme responsible for putrescine conversion, S-adenosylmethionine decarboxylase (SAMDC), in Caco-2 cells. Putrescine epidermal growth factor Homo sapiens
5 RESULTS: ODC and SAMDC activity and putrescine uptake were strongly stimulated by EGF. Putrescine epidermal growth factor Homo sapiens
6 Both synthesized and absorbed putrescine was rapidly converted to spermidine and spermine after EGF. Putrescine epidermal growth factor Homo sapiens