Title : Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation.

Pub. Date : 1999 Jan 15

PMID : 9880563






3 Functional Relationships(s)
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Protein Name
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1 The MCL1 member of the BCL2 family is up-regulated during the induction of monocytic differentiation (approximately 10-fold with 12-O-tetradecanoylphorbol 13-acetate (TPA)). Tetradecanoylphorbol Acetate MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 The MCL1 member of the BCL2 family is up-regulated during the induction of monocytic differentiation (approximately 10-fold with 12-O-tetradecanoylphorbol 13-acetate (TPA)). Tetradecanoylphorbol Acetate MCL1 apoptosis regulator, BCL2 family member Homo sapiens
3 Thus, the mechanism of the TPA-induced increase in MCL1 expression seen in myelomonocytic cells at early stages of differentiation involves signal transduction through ERKs and transcriptional activation through SRF/Elk-1. Tetradecanoylphorbol Acetate MCL1 apoptosis regulator, BCL2 family member Homo sapiens