Title : Bicarbonate is required for the peroxidase function of Cu, Zn-superoxide dismutase at physiological pH.

Pub. Date : 1999 Jan 15

PMID : 9880490






3 Functional Relationships(s)
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1 The results indicate that HCO3- competes with other anions for the anion-binding site of SOD1 (Arg141) but does not bind directly to the copper. Bicarbonates superoxide dismutase 1 Homo sapiens
2 Thus, SOD1 acquires peroxidase activity at physiological pH only in the presence of HCO3- or structurally similar anions. Bicarbonates superoxide dismutase 1 Homo sapiens
3 Alterations in pH that shift the HCO3-/CO2 equilibrium as occur in disease processes such as ischemia, sepsis, or shock would modulate the peroxidase function of SOD1. Bicarbonates superoxide dismutase 1 Homo sapiens