Pub. Date : 1998 Oct
PMID : 9876343
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The combined effects of GH and anabolic androgenic steroids on IGFBP-3 and IGF-I levels are not known under authentic substance-abusing conditions. | Steroids | insulin like growth factor binding protein 3 | Homo sapiens |
| 2 | Concomitant use of growth hormone and anabolic steroids decreased the IGFBP-3 concentration in five out of six abuse periods in spite of the fact that the IGF-I concentration remained elevated in four of them. | Steroids | insulin like growth factor binding protein 3 | Homo sapiens |
| 3 | However, in two men who were on low calorie diet both the IGF-I and IGFBP-3 concentrations decreased during combined GH/anabolic steroid abuse. | Steroids | insulin like growth factor binding protein 3 | Homo sapiens |
| 4 | CONCLUSION: Massive abuse of anabolic steroids decreases both the basal and GH-stimulated IGFBP-3 concentrations, whereas its effects on serum IGF-I concentration are variable and affected by low calorie diet. | Steroids | insulin like growth factor binding protein 3 | Homo sapiens |