Pub. Date : 1999 Jan 1
PMID : 9867869
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of translation relative to ER protein processing (cycloheximide) produced approximately 50% ADP-ribosylation of GRP78 within 90 min without eIF-2 phosphorylation. | Cycloheximide | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |
| 2 | Cycloheximide sharply reduced eIF-2 phosphorylation in response to ER stressors for about 30 min; sensitivity returned as GRP78 became increasingly ADP-ribosylated. | Cycloheximide | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |
| 3 | Prolonged (24 h) incubations with cycloheximide resulted in the selective loss of the ADP-ribosylated form of GRP78 and increased sensitivity of eIF-2 phosphorylation in response to ER stressors. | Cycloheximide | heat shock protein family A (Hsp70) member 5 | Rattus norvegicus |